[Update: See Disable AutoCAD InfoCenter]
In case you missed it, Tony Tanzillo has posted instructions for disabling the InfoCenter in AutoCAD 2010. AutoCAD 2010 starts faster when the InfoCenter is disabled.
To make it easy, I’ve created an AutoLISP file that defines commands named DisableInfoCenter and EnableInfoCenter:
Alternatively, you can just paste the following lisp at the AutoCAD command line to disable it and be done with it. Note that you need to restart AutoCAD for the change to take effect.
(vl-registry-write (strcat "HKEY_CURRENT_USER\" (vlax-product-key) "\InfoCenter") "InfoCenterOn" 0)